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Most AFib treatments manage the symptoms. We're focused on something different: addressing what's causing them in the first place.

Explore Comparisons Learn About AFib

What's Really Happening in AFib?

Nerves tell the heart when to beat. When those nerves are inflamed, the timing turns chaotic and the atria quiver instead of pumping. Each episode adds more inflammation and scarring, raising the risk of stroke and CHF.

AFib isn't really a heart problem. It's a nerve problem that appears in the heart.

Where Kaorta® fits

Standard care works downstream: slowing the rate, steadying the rhythm, thinning the blood, scarring the tissue. Kaorta® works upstream. A single IV infusion of PVC (perivascular) cells supports the body's effort to repair the nerves so the signal can steady on its own.

Age Of Diagnosis Is Critical

The earlier AFib starts, the more it takes. Patients diagnosed before age 50 can lose 9 to 11 years of life, more than any other age group, because they live with the cumulative risks for longer.

What those risks look like

AFib drives up to 20% of all strokes, since pooled blood in the quivering atria forms clots that can reach the brain. It also leads to heart failure, palpitations, fatigue, dizziness, and chest pain. Each episode adds inflammation and scarring, making the next one more likely.

Compare Your Options

Basic Advanced

Kaorta® Treatment

Surgical Ablation

Rate-Control Meds

Rhythm-Control Meds

Anticoagulants

Catheter Ablation

Basic comparison table for Kaorta, medication, and ablation.
Comparison Topic	Kaorta® Treatment	Surgical Ablation	Rate-Control Meds	Rhythm-Control Meds	Anticoagulants	Catheter Ablation
What Each Option Does

What it's trying to do	What it's trying to do Helps your body calm the inflammation that's disrupting the heartbeat signal Root Cause Focus	What it's trying to do A heart surgery option for hard cases, or a procedure that disconnects the heart's wiring and replaces it with a pacemaker	What it's trying to do Slows your heart so a fast or irregular rhythm feels less intense	What it's trying to do Tries to keep your heart in a steady rhythm while you're taking it	What it's trying to do Thins your blood so clots don't form during AFib and cause a stroke	What it's trying to do A doctor uses heat or cold inside your heart to scar the tissue causing the bad rhythm
What it looks like	What it looks like A one-time IV (intravenous) infusion. You sit in a clinic chair, the bag drips in, you go home the same day. Single Infusion	What it looks like Open or keyhole heart surgery, or a smaller procedure plus a permanent pacemaker put under your skin Heart Surgery	What it looks like A daily pill. Beta blockers or calcium channel blockers are the usual choices.	What it looks like A daily pill. Some need a short hospital stay to start safely so the doctor can watch your heart. Some Need Hospital Start	What it looks like A daily pill that thins your blood. Usually taken for life once you start.	What it looks like A hospital procedure. You're put to sleep, and a thin tube is threaded into your heart. Anesthesia
What to Watch Out For

The main catch	The main catch You still need a clinical review and scheduling. It doesn't replace your regular cardiology check-ins.	The main catch Reserved for hard cases. The pacemaker route means depending on it for life. Last-Line Option	The main catch It doesn't actually stop AFib or lower stroke risk. Your heart is still in AFib, just slower. Slows, Doesn't Stop	The main catch It often stops working over time. Doses or drugs may need to change. Wears Off	The main catch It doesn't stop AFib or change your rhythm. Bleeding risk lasts as long as you take it. Stroke Only	The main catch AFib often comes back. Many people end up needing a second procedure. Often Comes Back

Advanced comparison table for Kaorta, medication, and ablation.
Comparison Topic	Kaorta® Treatment	Surgical Ablation	Rate-Control Meds	Rhythm-Control Meds	Anticoagulants	Catheter Ablation
What Each Option Does

Primary goal	Primary goal Targets perivascular inflammation along the autonomic pathways modulating atrial conduction and contractility Root Cause Focus	Primary goal Cox-Maze lesion sets, hybrid epicardial-endocardial Convergent procedure, or AV-node ablation with permanent pacemaker for refractory cases	Primary goal Slows AV-nodal conduction to reduce the ventricular response during AFib episodes	Primary goal Pharmacologic maintenance of sinus rhythm via Class Ic, Class III, or multichannel-blocking agents	Primary goal Reduces thromboembolic stroke risk by inhibiting clot formation in the left atrial appendage	Primary goal Pulmonary-vein isolation (PVI) by radiofrequency, cryothermal, or pulsed-field energy to silence ectopic triggers
Common examples	Common examples Single IV infusion of autologous or donor-derived PVC (perivascular) cells, processed at BrioMD Labs prior to administration Single Infusion	Common examples Cox-Maze IV (full surgical Maze) Hybrid Convergent (epicardial + endocardial) AV-node ablation with permanent pacemaker	Common examples Beta blockers: metoprolol, bisoprolol, atenolol Non-DHP calcium channel blockers: diltiazem, verapamil Digoxin in select sedentary or HFrEF patients	Common examples Class III: amiodarone, sotalol, dofetilide, dronedarone Class Ic: flecainide, propafenone (without structural heart disease)	Common examples DOACs: apixaban, rivaroxaban, dabigatran, edoxaban Warfarin with INR target 2.0 to 3.0	Common examples Radiofrequency ablation Cryoballoon ablation Pulsed-field ablation (PFA)
Treatment format	Treatment format Outpatient IV infusion in a controlled clinical setting, physician-administered Outpatient IV	Treatment format Open sternotomy, thoracoscopic, or hybrid Convergent procedure, or AV-node ablation with permanent pacemaker implantation Cardiac Surgery	Treatment format Daily oral therapy, often combined with rhythm-control or anticoagulant agents	Treatment format Daily oral therapy. Sotalol and dofetilide require inpatient initiation with continuous QT monitoring. Inpatient Initiation	Treatment format Daily oral therapy, indefinite once initiated, with periodic kidney function checks	Treatment format Catheter-based intervention under conscious sedation or general anesthesia, typically same-day or one-night admission Anesthesia
Patient Experience

Time to reported effect	Time to reported effect Many patients report changes within 1 to 2 days. Responses vary. 1 to 2 Days	Time to reported effect Several weeks to months of recovery, depending on the procedure Long Recovery	Time to reported effect Within hours, while the medication is active	Time to reported effect Days to weeks, depending on the agent	Time to reported effect Stroke-risk reduction begins within days. No symptom change.	Time to reported effect Initial recovery takes weeks. Final rhythm picture is judged after a 3-month blanking period. Months to Settle
Repeat treatment	Repeat treatment Additional infusions may be scheduled based on response and clinician guidance	Repeat treatment Generally a one-time procedure, with medication and follow-up afterward One-Time Procedure	Repeat treatment Continues as prescribed. Doses adjust over time.	Repeat treatment Continues as prescribed. Drug class often changes if effect fades.	Repeat treatment Continues indefinitely once started, unless reassessed by a cardiologist	Repeat treatment Repeat ablation is common, particularly for persistent AFib May Repeat
Ongoing management	Ongoing management Follow-up through the patient's cardiologist Routine Follow-Up	Ongoing management Ongoing cardiology and pacemaker checks where applicable	Ongoing management Ongoing dosing, monitoring, refills, possible switches	Ongoing management Routine ECGs, lab work, and organ-toxicity monitoring with agents like amiodarone Toxicity Monitoring	Ongoing management Bleeding-risk monitoring, periodic kidney function checks. INR testing for warfarin. Bleeding Watch	Ongoing management Rhythm monitoring, often with extended ECG patches
Care Requirements

Before treatment	Before treatment Clinical review, harvest planning, lab processing, infusion scheduling	Before treatment Full cardiac evaluation. Often combined with another cardiac surgery. Surgical Workup	Before treatment Prescription based on history, blood pressure, heart-failure status, and other conditions	Before treatment Choice depends on structural heart disease, kidney function, QT interval, and prior agents	Before treatment Stroke-risk score, bleeding-risk score, kidney function	Before treatment Cardiac imaging, mapping plan, anesthesia clearance
Invasiveness	Invasiveness IV infusion after the harvest and processing steps IV Only	Invasiveness Cardiac surgery, or a separate ablation plus implanted pacemaker Procedure-Based	Invasiveness Non-procedural. Daily systemic medication.	Invasiveness Non-procedural. Daily systemic medication, with broader organ effects.	Invasiveness Non-procedural. Daily systemic medication.	Invasiveness Catheter procedure inside the heart Procedure-Based
Common risks or side effects	Common risks or side effects No known side effects have been reported. Patients are monitored during and after the infusion. None Reported	Common risks or side effects Standard cardiac surgery risks. Pacemaker dependence after AV-node ablation. Surgical Risks	Common risks or side effects Fatigue, low heart rate, low blood pressure, dizziness. Some agents are avoided in heart failure.	Common risks or side effects Proarrhythmia risk Long-term thyroid, lung, liver, eye, and skin effects with amiodarone QT prolongation with sotalol and dofetilide Organ Toxicity	Common risks or side effects Bleeding, with intracranial bleeding the most serious concern Bleeding Risk	Common risks or side effects Vascular access complications, pericardial effusion, phrenic nerve injury, rare atrioesophageal fistula Procedure Risks
Limits to Consider

Main limitation	Main limitation Requires clinical eligibility review, tissue harvest, lab processing, and scheduled infusion. Adjunctive to ongoing cardiology care.	Main limitation Reserved for refractory cases or concomitant cardiac surgery. AV-node ablation creates lifetime pacemaker dependence. Reserved Cases	Main limitation Symptomatic control only. The patient remains in AFib with attendant stroke risk and ongoing atrial remodeling. Symptom Only	Main limitation Long-term rhythm maintenance is modest. Efficacy declines and proarrhythmia risk persists with continued exposure. Effect Fades	Main limitation Stroke-risk reduction only. No effect on rhythm, rate, or atrial substrate. Bleeding risk persists for the duration of therapy. Stroke Risk Only	Main limitation Recurrence is common, particularly in persistent and long-standing persistent AFib. Repeat ablation rates of 20% to 40% are reported. Often Repeats

Educational Articles

Understand AFIB, solutions and more

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History of AFib

How atrial fibrillation was first described, what each generation of physicians could see, and where the field stands today.

What Is Cellular Infusion

What is cellular infusion, where the practice came from, and what makes one program different from the next.

Treatments for AFib

How AFib is managed today, what each treatment is designed to do, and where the standard playbook still leaves patients waiting.

Considering Kaorta® for Yourself or a Family Member?

Set up a consult and review the treatment schedule, travel plans and next steps.

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